Journal article
Direct Determination of Absolute Molecular Stereochemistry in Gas Phase by Coulomb Explosion Imaging



Publication Details
Authors:
Pitzer, M.; Kunitski, M.; Johnson, A.; Jahnke, T.; Sann, H.; Sturm, F.; Schmidt, L.; Schmidt-Böcking, H.; Dörner, R.; Stohner, J.; Kiedrowski, J.; Reggelin, M.; Marquardt, S.; Schießer, A.; Berger, R.; Schöffler, M.
Publication year:
2013
Journal:
Science
Pages range:
1096-1100
Volume number:
341
ISSN:
0036-8075

Abstract
Bijvoet's method, which makes use of anomalous x-ray diffraction or dispersion, is the standard means of directly determining the absolute (stereochemical) configuration of molecules, but it requires crystalline samples and often proves challenging in structures exclusively comprising light atoms.Herein, we demonstrate a mass spectrometry approach that directly images the absolute configuration of individual molecules in the gas phase by cold target recoil ion momentum spectroscopy after laser ionization-induced Coulomb explosion. This technique is applied to the prototypical chiral molecule bromochlorofluoromethane and the isotopically chiral methane derivative bromodichloromethane.


Authors/Editors

Last updated on 2019-25-07 at 17:06